› 4xjj

X-ray diffraction
1.4Å resolution

Extracellular domain of type II Transforming Growth Factor Beta receptor in complex with 2-(2-Hydroxyethyl)NDSB-201

Released:
DOI: 10.2210/pdb4xjj/pdb
PDB entry 4xjj coloured by chain, front view.
PDB entry 4xjj coloured by chain, side view.
PDB entry 4xjj coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Wangkanont K, Forest KT, Kiessling LL

Function and Biology Details

Reaction catalysed: 
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-153364 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
TGF-beta receptor type-2 Chain: A
Molecule details ›
Chain: A
Length: 112 amino acids
Theoretical weight: 12.76 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P37173 (Residues: 50-159; Coverage: 20%)
Gene name: TGFBR2
Sequence domains: Transforming growth factor beta receptor 2 ectodomain
Structure domains: CD59

Ligands and Environments

1 bound ligand:
Ligand 41D 1 x 41D
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-F
Spacegroup: P212121
Unit cell:
a: 35.17Å b: 40.373Å c: 76.341Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.154 0.153 0.185
Expression system: Escherichia coli BL21(DE3)

Quick links