› 4xpj

X-ray diffraction
2.6Å resolution

Crystal structure of Nerve growth factor in complex with lysophosphatidylinositol

Released:
DOI: 10.2210/pdb4xpj/pdb
PDB entry 4xpj coloured by chain, front view.
PDB entry 4xpj coloured by chain, side view.
PDB entry 4xpj coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The structure of nerve growth factor in complex with lysophosphatidylinositol.
Sun HL, Jiang T
Acta Crystallogr F Struct Biol Commun 71 906-12 (2015)
PMID: 26144237

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-134072 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Beta-nerve growth factor Chains: A, B
Molecule details ›
Chains: A, B
Length: 120 amino acids
Theoretical weight: 13.49 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P01139 (Residues: 122-241; Coverage: 54%)
Gene names: Ngf, Ngfb
Sequence domains: Nerve growth factor family
Structure domains: Cystine-knot cytokines

Ligands and Environments

1 bound ligand:
Ligand LPY 1 x LPY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: R32
Unit cell:
a: 96.689Å b: 96.689Å c: 164.339Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.199 0.195 0.266

Quick links

Citations

1 review citation

Role of NGF and its receptors in wound healing (Review).
Liu et al. (2021)
2 other articles

4 mentions without citation

Small Endogenous Ligands Modulation of Nerve Growth Factor Bioactivity: A Structural Biology Overview.
Paoletti et al. (2021)
3 more