› 4xqs

X-ray diffraction
2.3Å resolution

Crystal structure of human FPPS in complex with one magnesium ion

Released:
DOI: 10.2210/pdb4xqs/pdb
PDB entry 4xqs coloured by chain, front view.
PDB entry 4xqs coloured by chain, side view.
PDB entry 4xqs coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Park J, Berghuis AM

Function and Biology Details

Reactions catalysed: 
Prenyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate
Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146902 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Farnesyl pyrophosphate synthase Chain: F
Molecule details ›
Chain: F
Length: 375 amino acids
Theoretical weight: 43.14 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P14324 (Residues: 67-419; Coverage: 84%)
Gene names: FDPS, FPS, KIAA1293
Sequence domains: Polyprenyl synthetase
Structure domains: Farnesyl Diphosphate Synthase

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CLSI BEAMLINE 08ID-1
Spacegroup: P41212
Unit cell:
a: 110.77Å b: 110.77Å c: 76.97Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.192 0.232
Expression system: Escherichia coli

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