› 4xrz

X-ray diffraction
2.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145367 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cytochrome P450 2D6 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 479 amino acids
Theoretical weight: 53.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P10635 (Residues: 34-497; Coverage: 93%)
Gene names: CYP2D6, CYP2DL1
Sequence domains: Cytochrome P450
Structure domains: Cytochrome P450

Ligands and Environments

5 bound ligands:
Ligand HEM 4 x HEM
Ligand SI6 4 x SI6
Ligand ZN 12 x ZN
Ligand GOL 4 x GOL
Ligand NA 4 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P212121
Unit cell:
a: 57.543Å b: 192.48Å c: 244.883Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.254
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Highlights in BACE1 Inhibitors for Alzheimer's Disease Treatment.
Coimbra et al. (2018)
6 more

3 mentions without citation

Recent Structural Insights into Cytochrome P450 Function.
Guengerich et al. (2016)
2 more