› 4xsv

X-ray diffraction
2.7Å resolution

Human CTP: Phosphoethanolamine Cytidylyltransferase in complex with CTP

Released:
DOI: 10.2210/pdb4xsv/pdb
PDB entry 4xsv coloured by chain, front view.
PDB entry 4xsv coloured by chain, side view.
PDB entry 4xsv coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Schuler H, Karlberg T

Function and Biology Details

Reaction catalysed: 
CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-189197 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ethanolamine-phosphate cytidylyltransferase Chain: A
Molecule details ›
Chain: A
Length: 341 amino acids
Theoretical weight: 38.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q99447 (Residues: 18-356; Coverage: 87%)
Gene name: PCYT2
Sequence domains: Cytidylyltransferase-like
Structure domains: HUPs

Ligands and Environments

3 bound ligands:
Ligand C5P 1 x C5P
Ligand CTP 1 x CTP
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P41212
Unit cell:
a: 73.39Å b: 73.39Å c: 140.03Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.191 0.264
Expression system: Escherichia coli BL21(DE3)

Quick links