› 4xta

X-ray diffraction
2.5Å resolution

MECHANISMS OF PPARgamma ACTIVATION BY NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Released:
DOI: 10.2210/pdb4xta/pdb
PDB entry 4xta coloured by chain, front view.
PDB entry 4xta coloured by chain, side view.
PDB entry 4xta coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs.
Puhl AC, Milton FA, Cvoro A, Sieglaff DH, Campos JC, Bernardes A, Filgueira CS, Lindemann JL, Deng T, Neves FA, Polikarpov I, Webb P
Nucl Recept Signal 13 e004 (2015)
PMID: 26445566

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Assembly name:
PDBe Complex ID:
PDB-CPX-153368 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 278 amino acids
Theoretical weight: 31.73 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P37231 (Residues: 232-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:
Ligand DIF 2 x DIF
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: C2
Unit cell:
a: 92.4Å b: 62.12Å c: 117.18Å
α: 90° β: 101.02° γ: 90°
R-values:
R R work R free
0.215 0.212 0.274
Expression system: Escherichia coli

Quick links

Citations

11 review citations

Self-regulation of the inflammatory response by peroxisome proliferator-activated receptors.
Korbecki et al. (2019)
10 more

3 mentions without citation

Mechanisms of peroxisome proliferator activated receptor γ regulation by non-steroidal anti-inflammatory drugs.
Puhl et al. (2015)
2 more