› 4xw2

X-ray diffraction
2Å resolution

Structural basis for simvastatin competitive antagonism of complement receptor 3

Released:
DOI: 10.2210/pdb4xw2/pdb
PDB entry 4xw2 coloured by chain, front view.
PDB entry 4xw2 coloured by chain, side view.
PDB entry 4xw2 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3.
Jensen MR, Bajic G, Zhang X, Laustsen AK, Koldsø H, Skeby KK, Schiøtt B, Andersen GR, Vorup-Jensen T
J Biol Chem 291 16963-76 (2016)
PMID: 27339893

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145707 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-M Chain: A
Molecule details ›
Chain: A
Length: 198 amino acids
Theoretical weight: 22.48 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P11215 (Residues: 145-337; Coverage: 17%)
Gene names: CD11B, CR3A, ITGAM
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

2 bound ligands:
Ligand MG 1 x MG
Ligand SIM 1 x SIM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MAX II BEAMLINE I911-3
Spacegroup: P212121
Unit cell:
a: 56.38Å b: 57.69Å c: 58.4Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.192 0.189 0.232
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Structural Immunology of Complement Receptors 3 and 4.
Vorup-Jensen et al. (2018)
4 more

3 mentions without citation

Marketed drugs used for the management of hypercholesterolemia as anticancer armament.
Papanagnou et al. (2017)
2 more