› 4xz0

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155055 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase ZAP-70 Chain: A
Molecule details ›
Chain: A
Length: 262 amino acids
Theoretical weight: 29.53 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P43403 (Residues: 1-259; Coverage: 42%)
Gene names: SRK, ZAP70
Sequence domains: SH2 domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand 4N5 1 x 4N5
Ligand SO4 2 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P63
Unit cell:
a: 103.418Å b: 103.418Å c: 52.817Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.214 0.212 0.245
Expression system: Escherichia coli

Quick links

Citations

2 review citations

ZAP-70 in Signaling, Biology, and Disease.
Au-Yeung et al. (2018)
1 more