› 4y88

X-ray diffraction
1.45Å resolution

Crystal structure of the N-terminal domain of CEACAM8

Released:
DOI: 10.2210/pdb4y88/pdb
PDB entry 4y88 coloured by chain, front view.
PDB entry 4y88 coloured by chain, side view.
PDB entry 4y88 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Diverse oligomeric states of CEACAM IgV domains.
Bonsor DA, Günther S, Beadenkopf R, Beckett D, Sundberg EJ
Proc Natl Acad Sci U S A 112 13561-6 (2015)
PMID: 26483485

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152186 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Carcinoembryonic antigen-related cell adhesion molecule 8 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.07 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31997 (Residues: 34-141; Coverage: 34%)
Gene names: CEACAM8, CGM6
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments

4 bound ligands:
Ligand SO4 2 x SO4
Ligand GOL 2 x GOL
Ligand CL 2 x CL
Ligand PDO 1 x PDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL7-1
Spacegroup: P4132
Unit cell:
a: 94.336Å b: 94.336Å c: 94.336Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.147 0.145 0.18
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

The Roles of Carcinoembryonic Antigen in Liver Metastasis and Therapeutic Approaches.
Lee et al. (2017)
4 more

2 mentions without citation

Helicobacter pylori adhesin HopQ disrupts trans dimerization in human CEACAMs.
Moonens et al. (2018)
1 more