› 4yc6

X-ray diffraction
2.6Å resolution

Function and Biology Details

Reactions catalysed: 
ATP + a protein = ADP + a phosphoprotein
ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139065 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Cyclin-dependent kinase 1 Chains: A, C, E, G
Molecule details ›
Chains: A, C, E, G
Length: 297 amino acids
Theoretical weight: 34.14 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P06493 (Residues: 1-297; Coverage: 100%)
Gene names: CDC2, CDC28A, CDK1, CDKN1, P34CDC2
Sequence domains: Protein kinase domain
Structure domains:
Cyclin-dependent kinases regulatory subunit 1 Chains: B, D, F, H
Molecule details ›
Chains: B, D, F, H
Length: 85 amino acids
Theoretical weight: 10.51 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61024 (Residues: 1-79; Coverage: 100%)
Gene names: CKS1, CKS1B, PNAS-143, PNAS-16
Sequence domains: Cyclin-dependent kinase regulatory subunit
Structure domains: Cyclin-dependent kinase, regulatory subunit

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 66.817Å b: 147.531Å c: 87.297Å
α: 90° β: 92.06° γ: 90°
R-values:
R R work R free
0.227 0.225 0.267
Expression systems:
  • Spodoptera frugiperda
  • Escherichia coli

Quick links

Citations

9 review citations

Cyclin-dependent protein kinase inhibitors including palbociclib as anticancer drugs.
Roskoski R. (2016)
8 more

14 mentions without citation

Structural insights into the functional diversity of the CDK-cyclin family.
Wood et al. (2018)
13 more