4yci

X-ray diffraction
3.25Å resolution

non-latent pro-bone morphogenetic protein 9

Released:
Source organisms:
Primary publication:
Structure of bone morphogenetic protein 9 procomplex.
Proc Natl Acad Sci U S A 112 3710-5 (2015)
PMID: 25751889

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-193831 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
Growth/differentiation factor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 296 amino acids
Theoretical weight: 33.22 KDa
Source organism: Mus musculus
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9WV56 (Residues: 23-318; Coverage: 73%)
Gene names: Bmp9, Gdf2
Sequence domains: TGF-beta propeptide
Growth/differentiation factor 2 Chains: C, D
Molecule details ›
Chains: C, D
Length: 110 amino acids
Theoretical weight: 12.1 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: Q9UK05 (Residues: 320-429; Coverage: 27%)
Gene names: BMP9, GDF2
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
2 bound ligands:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Spacegroup: P3221
Unit cell:
a: 120.28Å b: 120.28Å c: 221.31Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.241 0.24 0.26
Expression system: Cricetulus griseus