› 4ydy

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF DARPIN 44C12V5 IN COMPLEX WITH HUMAN IL-4

Released:
DOI: 10.2210/pdb4ydy/pdb
PDB entry 4ydy coloured by chain, front view.
PDB entry 4ydy coloured by chain, side view.
PDB entry 4ydy coloured by chain, top view.
Source organisms:
Entry authors: Teplyakov A, Obmolova G, Gilliland G

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138514 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
DARPIN 44C12V5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 169 amino acids
Theoretical weight: 17.89 KDa
Source organism: synthetic construct
Expression system: Escherichia coli
Structure domains: Ankyrin repeat-containing domain
Interleukin-4 Chains: I, J
Molecule details ›
Chains: I, J
Length: 130 amino acids
Theoretical weight: 15.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P05112 (Residues: 25-153; Coverage: 100%)
Gene name: IL4
Sequence domains: Interleukin 4
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

2 bound ligands:
Ligand GOL 2 x GOL
Ligand ACT 1 x ACT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P212121
Unit cell:
a: 55.25Å b: 113.66Å c: 117.06Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.202 0.239
Expression system: Escherichia coli

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