4yjl

X-ray diffraction
2.1Å resolution

Crystal structure of APC-ARM in complexed with Amer1-A2

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-150354 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Adenomatous polyposis coli protein Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 354 amino acids
Theoretical weight: 39.27 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P25054 (Residues: 407-751; Coverage: 12%)
Gene names: APC, DP2.5
Sequence domains:
Structure domains: Leucine-rich Repeat Variant
APC membrane recruitment protein 1 Chains: G, H, I, J, K, L
Molecule details ›
Chains: G, H, I, J, K, L
Length: 13 amino acids
Theoretical weight: 1.52 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q5JTC6 (Residues: 496-508; Coverage: 1%)
Gene names: AMER1, FAM123B, WTX

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRF BEAMLINE BL17U
Spacegroup: P1
Unit cell:
a: 60.592Å b: 168.925Å c: 170.272Å
α: 60.29° β: 90.07° γ: 90.05°
R-values:
R R work R free
0.208 0.207 0.225
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided