› 4yo4

X-ray diffraction
1.6Å resolution

Crystal Structure of DAPK1 catalytic domain in complex with the hinge binding fragment phthalazine

Released:
DOI: 10.2210/pdb4yo4/pdb
PDB entry 4yo4 coloured by chain, front view.
PDB entry 4yo4 coloured by chain, side view.
PDB entry 4yo4 coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Grum-Tokars VL, Roy SM, Minasov G, Anderson WF, Watterson DM

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156788 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Death-associated protein kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 294 amino acids
Theoretical weight: 33.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P53355 (Residues: 2-285; Coverage: 20%)
Gene names: DAPK, DAPK1
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

4 bound ligands:
Ligand CL 4 x CL
Ligand ACT 1 x ACT
Ligand SO4 1 x SO4
Ligand 4FT 1 x 4FT
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-G
Spacegroup: P212121
Unit cell:
a: 47.004Å b: 62.523Å c: 88.537Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.158 0.157 0.185
Expression system: Escherichia coli

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