› 4yvf

X-ray diffraction
2.7Å resolution

Structure of S-adenosyl-L-homocysteine hydrolase

Released:
DOI: 10.2210/pdb4yvf/pdb
PDB entry 4yvf coloured by chain, front view.
PDB entry 4yvf coloured by chain, side view.
PDB entry 4yvf coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and structural analyses of S-adenosyl-L-homocysteine hydrolase inhibitors based on non-adenosine analogs.
Nakao A, Suzuki H, Ueno H, Iwasaki H, Setsuta T, Kashima A, Sunada S
Bioorg Med Chem 23 4952-4969 (2015)
PMID: 26037610

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149993 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Adenosylhomocysteinase Chains: A, B
Molecule details ›
Chains: A, B
Length: 432 amino acids
Theoretical weight: 47.77 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P23526 (Residues: 1-432; Coverage: 100%)
Gene names: AHCY, SAHH
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand NAI 2 x NAI
Ligand XFA 2 x XFA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL24XU
Spacegroup: C2221
Unit cell:
a: 91.528Å b: 134.15Å c: 185.164Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.199 0.239
Expression system: Escherichia coli

Quick links

Citations

2 mentions without citation

Functional and Pathological Roles of AHCY.
Vizán et al. (2021)
1 more