› 4z32

X-ray diffraction
3.04Å resolution

Crystal Structure of the FERM-SH2 Domains of Jak2

Released:
DOI: 10.2210/pdb4z32/pdb
PDB entry 4z32 coloured by chain, front view.
PDB entry 4z32 coloured by chain, side view.
PDB entry 4z32 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of the FERM-SH2 Module of Human Jak2.
McNally R, Toms AV, Eck MJ
PLoS One 11 e0156218 (2016)
PMID: 27227461

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130063 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 497 amino acids
Theoretical weight: 57.68 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60674 (Residues: 31-516; Coverage: 43%)
Gene name: JAK2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P21
Unit cell:
a: 118.193Å b: 188.742Å c: 118.585Å
α: 90° β: 113.87° γ: 90°
R-values:
R R work R free
0.258 0.257 0.276
Expression system: Trichoplusia ni

Quick links

Citations

7 review citations

The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects.
Dehkhoda et al. (2018)
6 more

12 mentions without citation

The Janus Kinase (JAK) FERM and SH2 Domains: Bringing Specificity to JAK-Receptor Interactions.
Ferrao et al. (2017)
11 more