› 4z35

X-ray diffraction
2.9Å resolution

Crystal Structure of Human Lysophosphatidic Acid Receptor 1 in complex with ONO-9910539

Released:
DOI: 10.2210/pdb4z35/pdb
PDB entry 4z35 coloured by chain, front view.
PDB entry 4z35 coloured by chain, side view.
PDB entry 4z35 coloured by chain, top view.
Source organisms:
Primary publication:
Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1.
Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, Chun J, Stevens RC, Hanson MA
Cell 161 1633-43 (2015)
PMID: 26091040

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-142127 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysophosphatidic acid receptor 1; Soluble cytochrome b562 Chain: A
Molecule details ›
Chain: A
Length: 464 amino acids
Theoretical weight: 52.61 KDa
Source organisms: Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q92633 (Residues: 2-232, 248-326; Coverage: 85%)
  • Canonical: P0ABE7 (Residues: 23-64, 73-127; Coverage: 92%)
Gene names: EDG2, LPA1, LPAR1, cybC
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand ON9 1 x ON9
Ligand 1WV 1 x 1WV
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D, APS BEAMLINE 23-ID-B
Spacegroup: P212121
Unit cell:
a: 34.61Å b: 112.4Å c: 155.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.266 0.265 0.279
Expression system: Spodoptera frugiperda

Quick links

Citations

25 review citations

Interaction of G protein coupled receptors and cholesterol.
Gimpl G. (2016)
24 more

32 mentions without citation

G protein-coupled receptors: structure- and function-based drug discovery.
Yang et al. (2021)
31 more