› 4z9m

X-ray diffraction
2.1Å resolution

Crystal structure of human sarcomeric mitochondrial creatine kinase

Released:
DOI: 10.2210/pdb4z9m/pdb
PDB entry 4z9m coloured by chain, front view.
PDB entry 4z9m coloured by chain, side view.
PDB entry 4z9m coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Rabeh WM, Tempel W, Nedyalkova L, Landry R, Arrowsmith CH, Edwards AM, Bountra C, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
ATP + creatine = ADP + phosphocreatine
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148082 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Creatine kinase S-type, mitochondrial Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 392 amino acids
Theoretical weight: 44.69 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P17540 (Residues: 27-416; Coverage: 93%)
Gene name: CKMT2
Sequence domains:
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand ADP 8 x ADP
Ligand UNX 71 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P1
Unit cell:
a: 93.057Å b: 106.058Å c: 114.932Å
α: 70.12° β: 84.57° γ: 68.61°
R-values:
R R work R free
0.203 0.202 0.236
Expression system: Escherichia coli BL21(DE3)

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