› 4z9v

X-ray diffraction
2.1Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146707 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Bcl-2-like protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 153 amino acids
Theoretical weight: 17.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q07817 (Residues: 1-208; Coverage: 65%)
Gene names: BCL2L, BCL2L1, BCLX
Sequence domains:
Translationally-controlled tumor protein Chains: C, D, E, F, G, H
Molecule details ›
Chains: C, D, E, F, G, H
Length: 21 amino acids
Theoretical weight: 2.46 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P13693 (Residues: 11-31; Coverage: 12%)
Gene name: TPT1

Ligands and Environments

2 bound ligands:
Ligand BCT 2 x BCT
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P41212
Unit cell:
a: 100.357Å b: 100.357Å c: 105.045Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.187 0.185 0.222
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

4 review citations

Dysregulation of TCTP in Biological Processes and Diseases.
Bommer et al. (2020)
3 more

3 mentions without citation

The Structural Biology of Bcl-xL.
Lee et al. (2019)
2 more