Function and Biology Details
Reaction catalysed:
Strict requirement for Asp at position P1 and has a preferred cleavage sequence of (Leu/Asp/Val)-Glu-Thr-Asp-|-(Gly/Ser/Ala)
Biochemical function:
Biological process:
Cellular component:
- not assigned
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Caspase-8 subunit p18 (preferred)
PDBe Complex ID:
PDB-CPX-172100 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Caspase-8
Molecule details ›
Chains: A, B
Length: 190 amino acids
Theoretical weight: 22.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Death effector domain
Structure domains: Death Domain, Fas
Length: 190 amino acids
Theoretical weight: 22.49 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical:
Q14790 (Residues: 2-188; Coverage: 39%)
Sequence domains: Death effector domain
Structure domains: Death Domain, Fas
Ligands and Environments
No bound ligands
No modified residues
Experiments and Validation Details
X-ray source:
RIGAKU MICROMAX-002+
Spacegroup:
P1
Expression system: Escherichia coli
