› 4zdv

X-ray diffraction
1.8Å resolution

Crystal structure of LC3 in complex with FAM134B LIR

Released:
DOI: 10.2210/pdb4zdv/pdb
PDB entry 4zdv coloured by chain, front view.
PDB entry 4zdv coloured by chain, side view.
PDB entry 4zdv coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Regulation of endoplasmic reticulum turnover by selective autophagy.
Khaminets A, Heinrich T, Mari M, Grumati P, Huebner AK, Akutsu M, Liebmann L, Stolz A, Nietzsche S, Koch N, Mauthe M, Katona I, Qualmann B, Weis J, Reggiori F, Kurth I, Hübner CA, Dikic I
Nature 522 354-8 (2015)
PMID: 26040720

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-190602 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microtubule-associated proteins 1A/1B light chain 3A Chain: A
Molecule details ›
Chain: A
Length: 132 amino acids
Theoretical weight: 15.39 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9H492 (Residues: 2-120; Coverage: 98%)
Gene name: MAP1LC3A
Sequence domains: Autophagy protein Atg8 ubiquitin like
Structure domains: Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P42212
Unit cell:
a: 62.17Å b: 62.17Å c: 74.41Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.186 0.184 0.223
Expression system: Escherichia coli

Quick links

Citations

199 review citations

Biological Functions of Autophagy Genes: A Disease Perspective.
Levine et al. (2019)
198 more

5 mentions without citation

Ubiquitin-like 3 as a new protein-sorting factor for small extracellular vesicles.
Takanashi et al. (2022)
4 more