Function and Biology Details
Reaction catalysed:
3,4-dihydroxyphenethylamine + 2 ascorbate + O(2) = noradrenaline + 2 monodehydroascorbate + H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- Tyramine beta-hydroxylase/Dopamine beta-hydroxylase
- PHM/PNGase F domain superfamily
- DOMON domain
- Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site
- Copper type II, ascorbate-dependent monooxygenase-like, C-terminal
- Copper type II ascorbate-dependent monooxygenase, C-terminal
- Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site
- Copper type II, ascorbate-dependent monooxygenase, N-terminal
3 more domains
Structure analysis Details
Assembly composition:
homo dimer (preferred)
Assembly name:
Dopamine beta-hydroxylase (preferred)
PDBe Complex ID:
PDB-CPX-140584 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (4 distinct):
Ligands and Environments
No modified residues
Experiments and Validation Details
X-ray source:
DIAMOND BEAMLINE I02
Spacegroup:
C2221
Expression system: Homo sapiens