› 4zes

X-ray diffraction
1.65Å resolution

Blood dendritic cell antigen 2 (BDCA-2) complexed with methyl-mannoside

Released:
DOI: 10.2210/pdb4zes/pdb
PDB entry 4zes coloured by chain, front view.
PDB entry 4zes coloured by chain, side view.
PDB entry 4zes coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2.
Jégouzo SA, Feinberg H, Dungarwalla T, Drickamer K, Weis WI, Taylor ME
J Biol Chem 290 16759-71 (2015)
PMID: 25995448

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186702 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-type lectin domain family 4 member C Chains: A, B
Molecule details ›
Chains: A, B
Length: 147 amino acids
Theoretical weight: 17.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WTT0 (Residues: 67-213; Coverage: 69%)
Gene names: BDCA2, CLEC4C, CLECSF11, CLECSF7, DLEC, HECL, UNQ9361/PRO34150
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

3 bound ligands:
Ligand MMA 2 x MMA
Ligand CA 2 x CA
Ligand MG 2 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 23-ID-D
Unit cell:
a: 37.713Å b: 69.576Å c: 117.506Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.175 0.173 0.214
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Recent insights into structures and functions of C-type lectins in the immune system.
Drickamer et al. (2015)
6 more

3 mentions without citation

What contributes to an effective mannose recognition domain?
Sager et al. (2017)
2 more