› 4zet

X-ray diffraction
2.9Å resolution

Blood dendritic cell antigen 2 (BDCA-2) complexed with GalGlcNAcMan

Released:
DOI: 10.2210/pdb4zet/pdb
PDB entry 4zet coloured by chain, front view.
PDB entry 4zet coloured by chain, side view.
PDB entry 4zet coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2.
Jégouzo SA, Feinberg H, Dungarwalla T, Drickamer K, Weis WI, Taylor ME
J Biol Chem 290 16759-71 (2015)
PMID: 25995448

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186702 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
C-type lectin domain family 4 member C Chains: A, B
Molecule details ›
Chains: A, B
Length: 147 amino acids
Theoretical weight: 17.16 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8WTT0 (Residues: 67-213; Coverage: 69%)
Gene names: BDCA2, CLEC4C, CLECSF11, CLECSF7, DLEC, HECL, UNQ9361/PRO34150
Sequence domains: Lectin C-type domain
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

Carbohydrate polymer : NEW Components: MAN, NAG, GAL
Carbohydrate polymer
1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL12-2
Unit cell:
a: 37.559Å b: 67.645Å c: 118.142Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.182 0.178 0.263
Expression system: Escherichia coli

Quick links

Citations

8 review citations

Recent insights into structures and functions of C-type lectins in the immune system.
Drickamer et al. (2015)
7 more

2 mentions without citation

A Novel Mechanism for Binding of Galactose-terminated Glycans by the C-type Carbohydrate Recognition Domain in Blood Dendritic Cell Antigen 2.
Jégouzo et al. (2015)
1 more