› 4zfx

X-ray diffraction
2.55Å resolution

Siderocalin-mediated recognition and cellular uptake of actinides

Released:
DOI: 10.2210/pdb4zfx/pdb
PDB entry 4zfx coloured by chain, front view.
PDB entry 4zfx coloured by chain, side view.
PDB entry 4zfx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Allred BE, Rupert PB, Gauny SS, An DD, Ralston CY, Sturzbecher-Hoehne M, Strong RK, Abergel RJ
Proc Natl Acad Sci U S A 112 10342-7 (2015)
PMID: 26240330

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160359 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Neutrophil gelatinase-associated lipocalin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 180 amino acids
Theoretical weight: 20.7 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P80188 (Residues: 21-198; Coverage: 100%)
Gene names: HNL, LCN2, NGAL
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

3 bound ligands:
Ligand TH 3 x TH
Ligand EB4 2 x EB4
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P41212
Unit cell:
a: 114.53Å b: 114.53Å c: 119.496Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.241 0.24 0.268
Expression system: Escherichia coli BL21

Quick links

Citations

5 review citations

Lipocalin 2: An Emerging Player in Iron Homeostasis and Inflammation.
Xiao et al. (2017)
4 more

1 mention without citation

Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides.
Allred et al. (2015)