› 4zh9

X-ray diffraction
2.66Å resolution

Crystal Structure of the Domain-Swapped Dimer Wild-Type of Human Cellular Retinol Binding Protein II

Released:
DOI: 10.2210/pdb4zh9/pdb
PDB entry 4zh9 coloured by chain, front view.
PDB entry 4zh9 coloured by chain, side view.
PDB entry 4zh9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates.
Assar Z, Nossoni Z, Wang W, Santos EM, Kramer K, McCornack C, Vasileiou C, Borhan B, Geiger JH
Structure 24 1590-8 (2016)
PMID: 27524203

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156130 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinol-binding protein 2 Chain: A
Molecule details ›
Chain: A
Length: 133 amino acids
Theoretical weight: 15.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50120 (Residues: 2-134; Coverage: 99%)
Gene names: CRBP2, RBP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family
Structure domains: Lipocalin

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 21-ID-D
Unit cell:
a: 36.851Å b: 60.544Å c: 64.021Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.2 0.274
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Protein Assembly by Design.
Zhu et al. (2021)
3 other articles

2 mentions without citation

Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
Ghanbarpour et al. (2019)
1 more