› 4zjk

X-ray diffraction
1.56Å resolution

FIVE MINUTES IRON LOADED HUMAN H FERRITIN

Released:
DOI: 10.2210/pdb4zjk/pdb
PDB entry 4zjk coloured by chain, front view.
PDB entry 4zjk coloured by chain, side view.
PDB entry 4zjk coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Iron binding to human heavy-chain ferritin.
Pozzi C, Di Pisa F, Bernacchioni C, Ciambellotti S, Turano P, Mangani S
Acta Crystallogr D Biol Crystallogr 71 1909-20 (2015)
PMID: 26327381

Function and Biology Details

Reaction catalysed: 
4 Fe(2+) + 4 H(+) + O(2) = 4 Fe(3+) + 2 H(2)O
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 24-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136244 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ferritin heavy chain Chain: A
Molecule details ›
Chain: A
Length: 182 amino acids
Theoretical weight: 21.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P02794 (Residues: 2-183; Coverage: 100%)
Gene names: FTH, FTH1, FTHL6, OK/SW-cl.84, PIG15
Sequence domains: Ferritin-like domain
Structure domains: Ferritin

Ligands and Environments

3 bound ligands:
Ligand FE2 5 x FE2
Ligand MG 5 x MG
Ligand CL 14 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: F432
Unit cell:
a: 183.8Å b: 183.8Å c: 183.8Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.169 0.168 0.192
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

5 review citations

Ferritins as natural and artificial nanozymes for theranostics.
Jiang et al. (2020)
4 more