› 4zml

X-ray diffraction
1.85Å resolution

Crystal structure of human P-cadherin (ss-dimer)

Released:
DOI: 10.2210/pdb4zml/pdb
PDB entry 4zml coloured by chain, front view.
PDB entry 4zml coloured by chain, side view.
PDB entry 4zml coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Adhesive Dimerization of Human P-Cadherin Catalyzed by a Chaperone-like Mechanism.
Kudo S, Caaveiro JM, Tsumoto K
Structure 24 1523-36 (2016)
PMID: 27545624

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-3 Chain: A
Molecule details ›
Chain: A
Length: 213 amino acids
Theoretical weight: 23.29 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22223 (Residues: 108-320; Coverage: 27%)
Gene names: CDH3, CDHP
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

4 bound ligands:
Ligand CA 5 x CA
Ligand CL 2 x CL
Ligand P6G 1 x P6G
Ligand PG4 1 x PG4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: C2
Unit cell:
a: 118.95Å b: 80.91Å c: 49.18Å
α: 90° β: 105.75° γ: 90°
R-values:
R R work R free
0.196 0.195 0.218
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions.
Mège et al. (2017)
1 more

1 mention without citation

Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin.
Kudo et al. (2017)