› 4zmq

X-ray diffraction
2.2Å resolution

Crystal structure of human P-cadherin (ss-X-dimer)

Released:
DOI: 10.2210/pdb4zmq/pdb
PDB entry 4zmq coloured by chain, front view.
PDB entry 4zmq coloured by chain, side view.
PDB entry 4zmq coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Adhesive Dimerization of Human P-Cadherin Catalyzed by a Chaperone-like Mechanism.
Kudo S, Caaveiro JM, Tsumoto K
Structure 24 1523-36 (2016)
PMID: 27545624

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 23.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22223 (Residues: 108-320; Coverage: 27%)
Gene names: CDH3, CDHP
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

2 bound ligands:
Ligand CA 8 x CA
Ligand 1PE 1 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P63
Unit cell:
a: 182.09Å b: 182.09Å c: 41.04Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.189 0.186 0.231
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions.
Mège et al. (2017)
1 more

2 mentions without citation

Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion.
Senoo et al. (2021)
1 more