› 4zmw

X-ray diffraction
2.3Å resolution

Crystal structure of human P-cadherin (enc-X-dimer)

Released:
DOI: 10.2210/pdb4zmw/pdb
PDB entry 4zmw coloured by chain, front view.
PDB entry 4zmw coloured by chain, side view.
PDB entry 4zmw coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Adhesive Dimerization of Human P-Cadherin Catalyzed by a Chaperone-like Mechanism.
Kudo S, Caaveiro JM, Tsumoto K
Structure 24 1523-36 (2016)
PMID: 27545624

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 214 amino acids
Theoretical weight: 23.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22223 (Residues: 108-320; Coverage: 27%)
Gene names: CDH3, CDHP
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

3 bound ligands:
Ligand CA 4 x CA
Ligand SO4 7 x SO4
Ligand NI 2 x NI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-5A
Spacegroup: C2
Unit cell:
a: 94.369Å b: 106.81Å c: 77.579Å
α: 90° β: 94.86° γ: 90°
R-values:
R R work R free
0.233 0.23 0.276
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions.
Mège et al. (2017)
1 more