› 4zmx

X-ray diffraction
3.1Å resolution

Crystal structure of human P-cadherin (int-X-dimer)

Released:
DOI: 10.2210/pdb4zmx/pdb
PDB entry 4zmx coloured by chain, front view.
PDB entry 4zmx coloured by chain, side view.
PDB entry 4zmx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Adhesive Dimerization of Human P-Cadherin Catalyzed by a Chaperone-like Mechanism.
Kudo S, Caaveiro JM, Tsumoto K
Structure 24 1523-36 (2016)
PMID: 27545624

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-149555 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-3 Chains: A, B
Molecule details ›
Chains: A, B
Length: 213 amino acids
Theoretical weight: 23.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P22223 (Residues: 108-320; Coverage: 27%)
Gene names: CDH3, CDHP
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE AR-NW12A
Spacegroup: P63
Unit cell:
a: 181.46Å b: 181.46Å c: 40.73Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.208 0.206 0.235
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 review citations

Integration of Cadherin Adhesion and Cytoskeleton at Adherens Junctions.
Mège et al. (2017)
1 more

1 mention without citation

A general method for directly phasing diffraction data from high-solvent-content protein crystals.
Kingston et al. (2022)