› 4zql

X-ray diffraction
1.79Å resolution

Crystal structure of TRIM24 with 3,4-dimethoxy-N-(6-(4-methoxyphenoxy)-1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)benzenesulfonamide inhibitor

Released:
DOI: 10.2210/pdb4zql/pdb
PDB entry 4zql coloured by chain, front view.
PDB entry 4zql coloured by chain, side view.
PDB entry 4zql coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Tallant C, Structural Genomics Consortium (SGC), Clark PGK, Vieira LCC, Krojer T, Nunez-Alonso G, Picaud S, Fedorov O, Dixon DJ, von Delft F, Arrowsmith CH, Edwards AM, Bountra C, Brennan PE, Knapp S

Function and Biology Details

Reaction catalysed: 
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127337 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcription intermediary factor 1-alpha Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 21.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15164 (Residues: 825-1006; Coverage: 17%)
Gene names: RNF82, TIF1, TIF1A, TRIM24
Sequence domains:
Structure domains:

Ligands and Environments

5 bound ligands:
Ligand ZN 4 x ZN
Ligand SO4 2 x SO4
Ligand DMS 1 x DMS
Ligand 4QH 1 x 4QH
Ligand 1PE 1 x 1PE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: C2
Unit cell:
a: 89.414Å b: 36.661Å c: 128.989Å
α: 90° β: 109.87° γ: 90°
R-values:
R R work R free
0.161 0.159 0.199
Expression system: Escherichia coli

Quick links