› 4zt1

X-ray diffraction
1.92Å resolution

Crystal structure of human E-Cadherin (residues 3-213) in x-dimer conformation

Released:
DOI: 10.2210/pdb4zt1/pdb
PDB entry 4zt1 coloured by chain, front view.
PDB entry 4zt1 coloured by chain, side view.
PDB entry 4zt1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal Structure of Human E-Cadherin-EC1EC2 in Complex with a Peptidomimetic Competitive Inhibitor of Cadherin Homophilic Interaction.
Nardone V, Lucarelli AP, Dalle Vedove A, Fanelli R, Tomassetti A, Belvisi L, Civera M, Parisini E
J Med Chem 59 5089-94 (2016)
PMID: 27120112

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146336 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cadherin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 211 amino acids
Theoretical weight: 22.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P12830 (Residues: 157-367; Coverage: 25%)
Gene names: CDH1, CDHE, UVO
Sequence domains: Cadherin domain
Structure domains: Cadherins

Ligands and Environments

1 bound ligand:
Ligand CA 6 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06DA
Spacegroup: C2
Unit cell:
a: 120.446Å b: 76.417Å c: 73.02Å
α: 90° β: 109.98° γ: 90°
R-values:
R R work R free
0.194 0.193 0.219
Expression system: Escherichia coli BL21(DE3)

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Citations

4 review citations

Guidance of Signaling Activations by Cadherins and Integrins in Epithelial Ovarian Cancer Cells.
Roggiani et al. (2016)
3 more

5 mentions without citation

A Framework of Paracellular Transport via Nanoparticles-Induced Endothelial Leakiness.
Lee et al. (2021)
4 more