› 4zvy

X-ray diffraction
1.9Å resolution

Structure of human ALDH7A1 complexed with NAD+ in space group P4212

Released:
DOI: 10.2210/pdb4zvy/pdb
PDB entry 4zvy coloured by chain, front view.
PDB entry 4zvy coloured by chain, side view.
PDB entry 4zvy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1.
Luo M, Tanner JJ
Biochemistry 54 5513-22 (2015)
PMID: 26260980

Function and Biology Details

Reactions catalysed: 
An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH
(1a) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O (spontaneous)
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-155949 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Alpha-aminoadipic semialdehyde dehydrogenase Chains: A, B
Molecule details ›
Chains: A, B
Length: 513 amino acids
Theoretical weight: 55.62 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P49419 (Residues: 29-539; Coverage: 95%)
Gene names: ALDH7A1, ATQ1
Sequence domains: Aldehyde dehydrogenase family
Structure domains:

Ligands and Environments


Cofactor: Ligand NAD 1 x NAD
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 4.2.2
Spacegroup: P4212
Unit cell:
a: 159.111Å b: 159.111Å c: 79.67Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.182 0.213
Expression system: Escherichia coli

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Citations

4 review citations

Molecular Mechanisms of Bacterial Bioluminescence.
Brodl et al. (2018)
3 more

1 mention without citation

Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1.
Luo et al. (2015)