› 4zwb

X-ray diffraction
2.4Å resolution

Crystal structure of maltose-bound human GLUT3 in the outward-occluded conformation at 2.4 angstrom

Released:
DOI: 10.2210/pdb4zwb/pdb
PDB entry 4zwb coloured by chain, front view.
PDB entry 4zwb coloured by chain, side view.
PDB entry 4zwb coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis of ligand recognition and transport by glucose transporters.
Deng D, Sun P, Yan C, Ke M, Jiang X, Xiong L, Ren W, Hirata K, Yamamoto M, Fan S, Yan N
Nature 526 391-6 (2015)
PMID: 26176916

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145689 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Solute carrier family 2, facilitated glucose transporter member 3 Chain: A
Molecule details ›
Chain: A
Length: 518 amino acids
Theoretical weight: 56.47 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P11169 (Residues: 1-496; Coverage: 100%)
Gene names: GLUT3, SLC2A3
Sequence domains: Sugar (and other) transporter
Structure domains: MFS general substrate transporter like domains

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL32XU
Spacegroup: P21
Unit cell:
a: 48.46Å b: 119.487Å c: 53.908Å
α: 90° β: 103.75° γ: 90°
R-values:
R R work R free
0.183 0.181 0.224
Expression system: Spodoptera frugiperda

Quick links

Citations

38 review citations

Shared Molecular Mechanisms of Membrane Transporters.
Drew et al. (2016)
37 more

19 mentions without citation

GLUT, SGLT, and SWEET: Structural and mechanistic investigations of the glucose transporters.
Deng et al. (2016)
18 more