› 4zzx

X-ray diffraction
1.65Å resolution

Function and Biology Details

Reaction catalysed: 
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193721 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Poly [ADP-ribose] polymerase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 363 amino acids
Theoretical weight: 41.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9UGN5 (Residues: 223-583; Coverage: 62%)
Gene names: ADPRT2, ADPRTL2, PARP2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand FSU 2 x FSU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P212121
Unit cell:
a: 72.46Å b: 72.74Å c: 141.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.213 0.244
Expression system: Escherichia coli BL21

Quick links

Citations

11 review citations

DNA repair targeted therapy: The past or future of cancer treatment?
Gavande et al. (2016)
10 more

7 mentions without citation

PARP Power: A Structural Perspective on PARP1, PARP2, and PARP3 in DNA Damage Repair and Nucleosome Remodelling.
van Beek et al. (2021)
6 more