› 4a04

X-ray diffraction
2.58Å resolution

Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome

Released:
DOI: 10.2210/pdb4a04/pdb
PDB entry 4a04 coloured by chain, front view.
PDB entry 4a04 coloured by chain, side view.
PDB entry 4a04 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structure of the DNA-bound T-box domain of human TBX1, a transcription factor associated with the DiGeorge syndrome.
El Omari K, De Mesmaeker J, Karia D, Ginn H, Bhattacharya S, Mancini EJ
Proteins 80 655-60 (2012)
PMID: 22095455

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117178 (preferred)
Entry contents:
1 distinct polypeptide molecule
1 distinct DNA molecule
Macromolecules (2 distinct):
T-box transcription factor TBX1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 203 amino acids
Theoretical weight: 23.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O43435 (Residues: 109-297; Coverage: 48%)
Gene name: TBX1
Sequence domains: T-box
Structure domains: Transcription factor, T-box
DNA Chains: D, E
Molecule details ›
Chains: D, E
Length: 24 nucleotides
Theoretical weight: 7.37 KDa
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I24
Spacegroup: P212121
Unit cell:
a: 71.42Å b: 92.74Å c: 101.02Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.208 0.206 0.227
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

3 review citations

The T-box gene family: emerging roles in development, stem cells and cancer.
Papaioannou VE. (2014)
2 more

7 mentions without citation

Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi.
Caloni et al. (2022)
6 more