› 4a0j

X-ray diffraction
2.8Å resolution

Crystal structure of Survivin bound to the phosphorylated N-terminal tail of histone H3

Released:
DOI: 10.2210/pdb4a0j/pdb
PDB entry 4a0j coloured by chain, front view.
PDB entry 4a0j coloured by chain, side view.
PDB entry 4a0j coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the recognition of phosphorylated histone h3 by the survivin subunit of the chromosomal passenger complex.
Jeyaprakash AA, Basquin C, Jayachandran U, Conti E
Structure 19 1625-34 (2011)
PMID: 22032967

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127456 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Baculoviral IAP repeat-containing protein 5 Chains: A, B
Molecule details ›
Chains: A, B
Length: 142 amino acids
Theoretical weight: 16.41 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: O15392 (Residues: 1-142; Coverage: 100%)
Gene names: API4, BIRC5, IAP4
Sequence domains: Inhibitor of Apoptosis domain
Structure domains: Inhibitor Of Apoptosis Protein (2mihbC-IAP-1); Chain A
Histone H3.1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 6 amino acids
Theoretical weight: 786 Da
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P68431 (Residues: 2-7; Coverage: 4%)
Gene names: H3C1, H3C10, H3C11, H3C12, H3C2, H3C3, H3C4, H3C6, H3C7, H3C8, H3FA, H3FB, H3FC HIST1H3C, H3FD, H3FF, H3FH, H3FI, H3FJ, H3FK, H3FL, HIST1H3A, HIST1H3B, HIST1H3D, HIST1H3E, HIST1H3F, HIST1H3G, HIST1H3H, HIST1H3I, HIST1H3J

Ligands and Environments

1 bound ligand:
Ligand ZN 2 x ZN
1 modified residue:
Ligand TPO 2 x TPO

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: C2
Unit cell:
a: 114.365Å b: 70.896Å c: 81.465Å
α: 90° β: 129.03° γ: 90°
R-values:
R R work R free
0.201 0.198 0.268
Expression system: Not provided

Quick links

Citations

24 review citations

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.
Carmena et al. (2012)
23 more

2 mentions without citation

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling.
Krenn et al. (2015)
1 more