› 4a53

Solution NMR

Structural basis of the Dcp1:Dcp2 mRNA decapping complex activation by Edc3 and Scd6

Released:
DOI: 10.2210/pdb4a53/pdb
PDB entry 4a53 coloured by chain, ensemble of 20 models, front view.
PDB entry 4a53 coloured by chain, ensemble of 20 models, side view.
PDB entry 4a53 coloured by chain, ensemble of 20 models, top view.
Source organism: Schizosaccharomyces pombe
Primary publication:
The structural basis of Edc3- and Scd6-mediated activation of the Dcp1:Dcp2 mRNA decapping complex.
Fromm SA, Truffault V, Kamenz J, Braun JE, Hoffmann NA, Izaurralde E, Sprangers R
EMBO J 31 279-90 (2012)
PMID: 22085934

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131733 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Enhancer of mRNA-decapping protein 3 Chain: A
Molecule details ›
Chain: A
Length: 125 amino acids
Theoretical weight: 14.02 KDa
Source organism: Schizosaccharomyces pombe
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O94752 (Residues: 1-121; Coverage: 27%)
Gene names: SPBC18E5.11c, SPBC23G7.01c, edc3
Structure domains: SH3 type barrels.

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 44%
Refinement method: XPLOR
Expression system: Escherichia coli BL21

Quick links

Citations

17 review citations

Towards a molecular understanding of microRNA-mediated gene silencing.
Jonas et al. (2015)
16 more

7 mentions without citation

ABC1K atypical kinases in plants: filling the organellar kinase void.
Lundquist et al. (2012)
6 more