› 4a5t

X-ray diffraction
3.49Å resolution

STRUCTURAL BASIS FOR THE CONFORMATIONAL MODULATION

Released:
DOI: 10.2210/pdb4a5t/pdb
PDB entry 4a5t coloured by chain, front view.
PDB entry 4a5t coloured by chain, side view.
PDB entry 4a5t coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the native plasminogen reveals an activation-resistant compact conformation.
Xue Y, Bodin C, Olsson K
J Thromb Haemost 10 1385-96 (2012)
PMID: 22540246

Function and Biology Details

Reaction catalysed: 
Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa, higher selectivity than trypsin. Converts fibrin into soluble products.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-133230 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Plasminogen Chain: S
Molecule details ›
Chain: S
Length: 791 amino acids
Theoretical weight: 88.54 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P00747 (Residues: 20-810; Coverage: 100%)
Gene name: PLG
Sequence domains:
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NGA, GAL, SIA
Carbohydrate polymer
1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P43212
Unit cell:
a: 118.46Å b: 118.46Å c: 179.25Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.208 0.25

Quick links

Citations

23 review citations

Bacterial plasminogen receptors utilize host plasminogen system for effective invasion and dissemination.
Bhattacharya et al. (2012)
22 more

6 mentions without citation

Protons Potentiate GluN1/GluN3A Currents by Attenuating Their Desensitisation.
Cummings et al. (2016)
5 more