› 4aac

X-ray diffraction
2.5Å resolution

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172487 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase 14 Chain: A
Molecule details ›
Chain: A
Length: 365 amino acids
Theoretical weight: 42.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q16539 (Residues: 2-360; Coverage: 100%)
Gene names: CSBP, CSBP1, CSBP2, CSPB1, MAPK14, MXI2, SAPK2A
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand AAV 1 x AAV
Ligand CL 1 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P212121
Unit cell:
a: 64.511Å b: 75.073Å c: 76.899Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.234 0.23 0.305
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

2 citation in other articles

Anti-Inflammation of N-Benzyl-4-Bromobenzamide in Lipopolysaccharide-Induced Human Gingival Fibroblasts.
Aroonrerk et al. (2016)
1 more

2 mentions without citation

Structural basis of a redox-dependent conformational switch that regulates the stress kinase p38α.
Pous et al. (2023)
1 more