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HLA-DR1 with covalently linked CLIP106-120 in canonical orientation

X-ray diffraction
2.36Å resolution
PDB entry 4ah2 coloured by chain, front view.
PDB entry 4ah2 coloured by chain, side view.
PDB entry 4ah2 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero dimer (preferred)
Entry contents: 2 distinct polypeptide molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: HLA class II histocompatibility antigen,
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Multimeric state: hetero dimer
Accessible surface area: 17627.67 Å2
Buried surface area: 6887.99 Å2
Dissociation area: 3,076.45 Å2
Dissociation energy (ΔGdiss): 41.16 kcal/mol
Dissociation entropy (TΔSdiss): 13.26 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-135304

Macromolecules

HLA class II histocompatibility antigen, DR alpha chain
Chain: A
Length: 193 amino acids
Theoretical weight: 22.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01903 (Residues: 26-217; Coverage: 84%)
Gene names: HLA-DRA, HLA-DRA1
Pfam:
InterPro:
CATH:
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 4ah2, assembly 1, front view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 4ah2, assembly 1, side view.
HLA class II histocompatibility antigen, DR alpha chain in PDB entry 4ah2, assembly 1, top view.
Molecule details ›

Search similar proteins

Class-II-associated invariant chain peptide; HLA class II histocompatibility antigen, DRB1 beta chain
Chain: B
Length: 229 amino acids
Theoretical weight: 25.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P04233 (Residues: 106-120; Coverage: 5%)
  • Canonical: P01911 (Residues: 30-227; Coverage: 84%)
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Gene names: CD74, DHLAG, HLA-DRB1
Pfam:
InterPro:
CATH:
Class-II-associated invariant chain peptide in PDB entry 4ah2, assembly 1, front view.
Class-II-associated invariant chain peptide in PDB entry 4ah2, assembly 1, side view.
Class-II-associated invariant chain peptide in PDB entry 4ah2, assembly 1, top view.
Molecule details ›

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