› 4aot

X-ray diffraction
2.33Å resolution

Crystal Structure of Human Serine Threonine Kinase-10 (LOK) Bound to GW830263A

Released:
DOI: 10.2210/pdb4aot/pdb
PDB entry 4aot coloured by chain, front view.
PDB entry 4aot coloured by chain, side view.
PDB entry 4aot coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Elkins JM, Salah E, Szklarz M, Canning P, von Delft F, Yue W, Liu Y, Bountra C, Arrowsmith C, Edwards A, Knapp S

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131759 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Serine/threonine-protein kinase 10 Chains: A, B
Molecule details ›
Chains: A, B
Length: 302 amino acids
Theoretical weight: 34.3 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O94804 (Residues: 18-317; Coverage: 31%)
Gene names: LOK, STK10
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand CL 6 x CL
Ligand GW8 2 x GW8
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04-1
Spacegroup: P212121
Unit cell:
a: 55.69Å b: 87.51Å c: 148.59Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.219 0.217 0.252
Expression system: Escherichia coli BL21(DE3)

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