› 4as7

X-ray diffraction
2.4Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156612 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kinesin-like protein KIF11 Chain: A
Molecule details ›
Chain: A
Length: 368 amino acids
Theoretical weight: 41.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P52732 (Residues: 1-368; Coverage: 35%)
Gene names: EG5, KIF11, KNSL1, TRIP5
Sequence domains: Kinesin motor domain
Structure domains: Kinesin motor domain

Ligands and Environments

5 bound ligands:
Ligand ADP 1 x ADP
Ligand CL 4 x CL
Ligand CO 1 x CO
Ligand CD 6 x CD
Ligand 6LX 1 x 6LX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I03
Spacegroup: P65
Unit cell:
a: 81.07Å b: 81.07Å c: 123.961Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.162 0.159 0.212
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

1 review citation

Recent findings and future directions for interpolar mitotic kinesin inhibitors in cancer therapy.
Myers et al. (2016)
13 other articles

1 mention without citation

Kinesin Motor Enzymology: Chemistry, Structure, and Physics of Nanoscale Molecular Machines.
Cochran JC. (2015)