› 4avp

X-ray diffraction
1.82Å resolution

Crystal structure of the DNA-binding domain of human ETV1.

Released:
DOI: 10.2210/pdb4avp/pdb
PDB entry 4avp coloured by chain, front view.
PDB entry 4avp coloured by chain, side view.
PDB entry 4avp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structures of the Ets Protein DNA-binding Domains of Transcription Factors Etv1, Etv4, Etv5, and Fev: DETERMINANTS OF DNA BINDING AND REDOX REGULATION BY DISULFIDE BOND FORMATION.
Cooper CD, Newman JA, Aitkenhead H, Allerston CK, Gileadi O
J Biol Chem 290 13692-709 (2015)
PMID: 25866208

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156221 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ETS translocation variant 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 106 amino acids
Theoretical weight: 12.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P50549 (Residues: 326-429; Coverage: 22%)
Gene names: ER81, ETV1
Sequence domains: Ets-domain
Structure domains: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain

Ligands and Environments

1 bound ligand:
Ligand EDO 2 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I04
Spacegroup: P1
Unit cell:
a: 33.317Å b: 45.607Å c: 55.406Å
α: 77.89° β: 84.8° γ: 90.02°
R-values:
R R work R free
0.223 0.221 0.258
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Genetic-epigenetic interactions in cis: a major focus in the post-GWAS era.
Do et al. (2017)
2 more

4 mentions without citation

Recent advances in the structural molecular biology of Ets transcription factors: interactions, interfaces and inhibition.
Cooper et al. (2014)
3 more