› 4ay1

X-ray diffraction
1.95Å resolution

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide binding properties

Released:
DOI: 10.2210/pdb4ay1/pdb
PDB entry 4ay1 coloured by chain, front view.
PDB entry 4ay1 coloured by chain, side view.
PDB entry 4ay1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.
Schimpl M, Rush CL, Betou M, Eggleston IM, Recklies AD, van Aalten DM
Biochem J 446 149-57 (2012)
PMID: 22742450

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-172395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Chitinase-3-like protein 2 Chains: A, B, C, D, E, F, G, H, I, J, K, L
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 365 amino acids
Theoretical weight: 40.99 KDa
Source organism: Homo sapiens
Expression system: Komagataella phaffii GS115
UniProt:
  • Canonical: Q15782 (Residues: 26-390; Coverage: 100%)
Gene name: CHI3L2
Sequence domains: Glycosyl hydrolases family 18
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: C2
Unit cell:
a: 255.686Å b: 152.543Å c: 138.186Å
α: 90° β: 94.62° γ: 90°
R-values:
R R work R free
0.192 0.191 0.239
Expression system: Komagataella phaffii GS115

Quick links

Citations

14 review citations

Diverse pathological implications of YKL-40: answers may lie in 'outside-in' signaling.
Prakash et al. (2013)
13 more

2 mentions without citation

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.
Schimpl et al. (2012)
1 more