› 4bgn

Electron crystallography
9Å resolution

cryo-EM structure of the NavCt voltage-gated sodium channel

Released:
DOI: 10.2210/pdb4bgn/pdb
PDB entry 4bgn coloured by chain, front view.
PDB entry 4bgn coloured by chain, side view.
PDB entry 4bgn coloured by chain, top view.
Source organism: Caldalkalibacillus thermarum
Primary publication:
Two alternative conformations of a voltage-gated sodium channel.
Tsai CJ, Tani K, Irie K, Hiroaki Y, Shimomura T, McMillan DG, Cook GM, Schertler GF, Fujiyoshi Y, Li XD
J Mol Biol 425 4074-88 (2013)
PMID: 23831224
Related structures: EMD-2347

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-123584 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ion transport domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 298 amino acids
Theoretical weight: 34.48 KDa
Source organism: Caldalkalibacillus thermarum
Expression system: Escherichia coli
UniProt:
  • Canonical: F5L478 (Residues: 1-298; Coverage: 100%)
Gene names: CathTA2_0590, HUR95_02030
Sequence domains: Ion transport protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 9Å
Relevant EMDB volumes: EMD-2347
Expression system: Escherichia coli

Quick links

Citations

9 review citations

The hitchhiker's guide to the voltage-gated sodium channel galaxy.
Ahern et al. (2016)
8 more

9 mentions without citation

Bacterial voltage-gated sodium channels (BacNa(V)s) from the soil, sea, and salt lakes enlighten molecular mechanisms of electrical signaling and pharmacology in the brain and heart.
Payandeh et al. (2015)
8 more