› › Structure analysis

Scaffold Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitor

X-ray diffraction
2.84Å resolution
PDB entry 4bi0 coloured by chain, front view.
PDB entry 4bi0 coloured by chain, side view.
PDB entry 4bi0 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

Quick links

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Assembly Name: Dual specificity protein kinase TTK
hide full assembly name
Multimeric state: monomeric
Accessible surface area: 12235.84 Å2
Buried surface area: 1082.75 Å2
Dissociation area: 105.65 Å2
Dissociation energy (ΔGdiss): -1.48 kcal/mol
Dissociation entropy (TΔSdiss): -0.39 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-152667

Macromolecules

Dual specificity protein kinase TTK
Chain: A
Length: 313 amino acids
Theoretical weight: 36.12 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P33981 (Residues: 519-808; Coverage: 34%)
Gene names: MPS1, MPS1L1, TTK
Pfam: Protein kinase domain
InterPro:
CATH:
Dual specificity protein kinase TTK in PDB entry 4bi0, assembly 1, front view.
Dual specificity protein kinase TTK in PDB entry 4bi0, assembly 1, side view.
Dual specificity protein kinase TTK in PDB entry 4bi0, assembly 1, top view.
Molecule details ›

Search similar proteins

Quick links