Function and Biology Details
Reaction catalysed:
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone
Biochemical function:
Biological process:
Cellular component:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171642 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Metastasis-associated protein MTA1
Molecule details ›
Chain: A
Length: 176 amino acids
Theoretical weight: 19.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains:
Structure domains:
Length: 176 amino acids
Theoretical weight: 19.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical:
Q13330 (Residues: 162-335; Coverage: 24%)
Sequence domains:
Structure domains:
Histone deacetylase 1
Molecule details ›
Chain: B
Length: 482 amino acids
Theoretical weight: 55.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain
Length: 482 amino acids
Theoretical weight: 55.18 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
- Canonical: Q13547 (Residues: 1-482; Coverage: 100%)
Sequence domains: Histone deacetylase domain
Structure domains: Histone deacetylase domain
