Function and Biology

Crystal structure of 3-oxoacyl-(acyl-carrier-protein) reductase (FabG) from Pseudomonas aeruginosa in complex with 2-(trifluoromethyl)-1H- benzimidazole at 2.3A resolution

Source organism: Pseudomonas aeruginosa PAO1
Biochemical function: NAD binding
Biological process: fatty acid elongation
Cellular component: not assigned

EC 1.1.1.100: 3-oxoacyl-[acyl-carrier-protein] reductase

Reaction catalysed:
(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH
Systematic name:
(3R)-3-hydroxyacyl-[acyl-carrier-protein]:NADP(+) oxidoreductase
Alternative Name(s):
  • 3-ketoacyl acyl carrier protein reductase
  • 3-oxoacyl-[ACP]reductase
  • Beta-ketoacyl acyl carrier protein (ACP) reductase
  • Beta-ketoacyl reductase
  • Beta-ketoacyl thioester reductase
  • Beta-ketoacyl-ACP reductase
  • Beta-ketoacyl-[acyl-carrier protein](ACP) reductase
  • Beta-ketoacyl-acyl carrier protein reductase
  • NADPH-specific 3-oxoacyl-[acylcarrier protein]reductase

Sequence family

Pfam Protein family (Pfam)
PF13561
Domain description: Enoyl-(Acyl carrier protein) reductase
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase FabG
The deposited structure of PDB entry 4bnt contains 4 copies of Pfam domain PF13561 (Enoyl-(Acyl carrier protein) reductase) in 3-oxoacyl-[acyl-carrier-protein] reductase FabG. Showing 1 copy in chain D.

InterPro InterPro annotations
IPR002347
Domain description: Short-chain dehydrogenase/reductase SDR
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase FabG
IPR020904
Domain description: Short-chain dehydrogenase/reductase, conserved site
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase FabG
IPR011284
Domain description: 3-oxoacyl-(acyl-carrier-protein) reductase
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase FabG
IPR036291
Domain description: NAD(P)-binding domain superfamily
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase FabG

Structure domain

CATH CATH domain
3.40.50.720
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: NAD(P)-binding Rossmann-like Domain
Occurring in:
  1. 3-oxoacyl-[acyl-carrier-protein] reductase FabG
The deposited structure of PDB entry 4bnt contains 4 copies of CATH domain 3.40.50.720 (Rossmann fold) in 3-oxoacyl-[acyl-carrier-protein] reductase FabG. Showing 1 copy in chain D.